Stem Cell-Derived Motor Neurons Go Out on a Limb

Methods to create motor neurons from embryonic and induced pluripotent stem cells are well established.  However the motor neurons that are typically formed represent only one type of motor neuron found in vivo, which is associated with innervation of axial (vertebral) muscles.  Our study, recently published in Nature Communications describes an approach for generating high numbers of limb-innervating motor neurons from stem cells using the transcription factor Foxp1.  These results present an effective approach for generating specific MN populations from stem cells for studying motor neuron development and disease.  Click [here] for a link to the article.

Two news releases related to our publication can be found [here] and [here].