Publications

2023
Wang Y, Li Q, Tao B, Angelini M, Ramadoss S, Sun B, Wang P, Krokhaleva Y, Ma Feiyang, Gu Y, Espinoza A, Yamauchi K, Pellegrini M, Novitch B, Olcese R, Qu Z, Song Z, Deb A. 
 Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis. Science 2023, in press.
 
Gupta S, Heinrichs E, Novitch BG, Butler SJ. Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses. bioRxiv. 2023 Jul 26:2023.07.24.550380. doi: 10.1101/2023.07.24.550380. Preprint. [Abstract] [Article]
 
Stearns-Reider KM, Hicks MR, Hammond KG, Reynolds JC, Maity A, Kurmangaliyev YZ, Chin J, Stieg AZ, Geisse NA, Hohlbauch S, Kaemmer S, Schmitt LR, Pham TT, Yamauchi K, Novitch BG, Wollman R, Hansen KC, Pyle AD, Crosbie RH. Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis. NPJ Regen Med. 2023 Mar 15;8(1):16. [Abstract] [Article]
 
Li J, Godoy MI, Zhang AJ, Diamante G, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, Zhang Y. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis. bioRxiv 2023.02.14.528567. [Abstract] [Article]
 
2022
Pearson CA, Buth JE, Harrison MRM, Ross ME, Novitch BG. Foxp1 acts upstream of Vegfa, suppresses cortical angiogenesis, and promotes hypoxia in radial glia bioRxiv 2022.10.17.512545. [Abstract] [Article]
 
Wang J, Yang L, Jiang M, Zhao C, Liu X, Berry K, Waisman A, Langseth AJ, Novitch BG, Bergles DE, Nishiyama A, Lu QR. Olig2 ablation in immature oligodendrocytes does not enhance CNS myelination and remyelination. J Neurosci. 2022 Oct 3:JN-RM-0237-22. [Abstract] [Article]
 
Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 Oct 11;17(10):2220-2238. [Abstract] [Article]
 
Gupta S, Kawaguchi R, Heinrichs E, Gallardo S, Castellanos S, Mandric I, Novitch BG, Butler SJ. In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion. Cell Rep. 2022 Jul 19;40(3):111119. doi: 10.1016/j.celrep.2022.111119. [Abstract] [Article]
 
Li LK, Huang WC, Hsueh YY, Yamauchi K, Olivares N, Davila R, Fang J, Ding X, Zhao W, Soto J, Hasani M, Novitch B, Li S. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Res Ther. 2022 May 16;13(1):205.  [Abstract] [Article]
PMID: 35578348 
 
2021 
Taniguchi-Ikeda M, Koyanagi-Aoi M, Maruyama T, Takaori T, Hosoya A, Tezuka H, Nagase S, Ishihara T, Kadoshima T, Muguruma K, Ishigaki K, Sakurai H, Mizoguchi A, Novitch BG, Toda T, Watanabe M, Aoi T. Restoration of the defect in radial glial fiber cell migration and cortical plate organization in brain organoid model of Fukuyama muscular dystrophy. iScience. 2021; doi: 10.1016/j.isci.2021.103140. [Abstract] [Article]
 
Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, A SR, Pouladakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis. Stem Cell Reports, 2021 Sep 6:S2213-6711(21)00424-0. [Abstract] [Article]
 
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion N, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat. Neurosci. 2021 epub Aug 23; 24:1488-1500. see also bioRxiv. 2021; 820183. [Abstract] [Article]
 
Gupta S, Yamauchi K, Novitch BG, Butler SJ. Derivation of dorsal spinal sensory interneurons from human pluripotent stem cells. STAR Protoc. 2021 Feb 3;2(1):100319. [Abstract] [Article]
 
2020 
Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajauregui A, Novitch BG. Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. Cell Reports. 2020 Feb 11; 30(6):1964-81 e3. [Abstract] [Article]
 
2019
Watanabe M, Haney JR, Vishlaghi N, Turcios F, Buth JE, Gu W, Collier AJ, Miranda OA, Chen D, Sabri S, Clark AT, Plath K, Christofk HR, Gandal MJ, Novitch BG. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and competency to create telencephalic organoids. bioRxiv. 2019 Dec 13; 875773. [Abstract] [Article]
 
Samarasinghe RA, Miranda OA, Mitchell S, Ferando I, Watanabe M, Buth JE, Kurdian A, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. bioRxiv. 2019 Oct 28; 820183. [Abstract] [Article]
 
Andrews MG, Kong J, Novitch BG, Butler SJ. New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord. Curr Top Dev Biol. 2019 Feb 25; 132:417-50. [Abstract] [Article]
 
2018
Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG. Foxp1 controls neural stem cell competence and bias towards deep layer cortical fates. bioRxiv. 2018 Aug 7; 386276. [Abstract] [Article]
 
Han AY, Gupta S, Novitch BG. Molecular specification of facial branchial motor neurons in vertebrates. Dev Biol. 2018 Feb 3;436(1):5-13. [Abstract] [Article]
 
Sagner A*, Gaber ZB*, Delile J*, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J^, Novitch BG^. Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biol. 2018 Feb 1;16(2):e2003127. [Abstract] [Article]
 
2017
Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Reports. 2017 Oct 10;21(2):517-32. [Abstract] [Article]
 
Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. [Abstract] [Article]
 
Varadarajan SG, Kong JH, Phan KD, Kao T-J, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ. Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord  Neuron. 2017 April 20; 94:1-10. [Abstract] [Article]
 
Li C, Deng Y-Q, Wang S, Aliyari R, Huang X-Y, Zhang N-N, Watanabe M, Dong H-L, Liu P, Li X-F, Ye Q, Tian M, Hong S, Fan J, Zhao H, Vishlaghi N, Buth JE, Au C, Liu Y, Lu N, Du P, Qin X-F, Zhang B, Gong D, Dai X, Sun R, Novitch BG^, Xu Z, Qin C-F^, Cheng G^. 25-Hydroxycholesterol protects host against Zika virus infection and its associated microcephaly in a mouse model. Immunity. 2017 Mar 21;46(3):446-456. [Abstract] [Article]
 
Huang C, Su T, Xue Y, Cheng C, Lay FD, McKee RA, Li M, Vashisht A, Wohlschlegel J, Novitch BG, Plath K, Kurdistani SK, Carey M. Genes Dev. 2017 Feb 1;31(3):241-246. [Abstract] [Article]
 
2015
Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL.  The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. eLife. 2015 Dec 24;4. pii: e09268. doi:10.7554/eLife.09268. [Abstract] [Article]
 
Kong JH*, Yang L*, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch  BG. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87. [Abstract] [Article] [Cover art] [Preview] [Science Signaling Editor's Choice]
 
Adams KL, Rousso DL, Umbach JA, Novitch BG. Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015 Apr 14;6:6778. [Abstract] [Article]
 
2014
Pearson CA, Butler SJ, Novitch BG. Neuronal organization: unsticking the cadherin code. Curr Biol. 2014 Dec 1;24(23):R1127-9. [Abstract] [Article]
 
Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep. 2014 Jan 16;6(1):168-81. [Abstract] [Article]
 
2013
Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43. [Abstract] [Article]
 
Gaber ZB, Butler SJ, Novitch BG. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013 Oct;11(10):e1001676. [Abstract] [Article] [Cover Art]
 
Kong JH, Butler SJ, Novitch BG. My brain told me to do it. Dev Cell. 2013 Jun  10;25(5):436-8. [Abstract] [Article]
 
Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J,  Imayoshi I, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J. Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol. 2013 Mar 4;23(5):412-8. [Abstract] [Article]
 
2012
Wang Y, Kim E, Wang X, Novitch BG, Yoshikawa K, Chang LS, Zhu Y. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell. 2012 Aug 17;150(4):816-30. [Abstract] [Article]
 
Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F. Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012 Sep;139(17):3109-19. [Abstract] [Article]
 
Umbach JA, Adams KL, Gundersen CB, Novitch BG. Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. PLoS One. 2012;7(5):e36049. [Abstract] [Article]
 
Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG. Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 2012 Apr 26;74(2):314-30. [Abstract] [Article] [Cover Art] [Preview]
 
Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron.  2012 Apr 12;74(1):79-94. [Abstract] [Article]
 
2011
Skaggs K, Martin DM, Novitch BG. Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development. 2011 Aug;138(15):3199-211. [Abstract] [Article]
 
Gaber ZB, Novitch BG. All the embryo's a stage, and Olig2 in its time plays many parts. Neuron. 2011 Mar 10;69(5):833-5. [Abstract] [Article]
 
Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB. Npn-1 contributes to  axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011 Feb;9(2):e1001020. [Abstract] [Article]
 
2010
Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010 Aug 10;8(8):e1000446. [Abstract] [Article]
 
Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N. Dynamic assignment and maintenance of positional identity in  the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol. 2010 Jun 1;8(6):e1000382. [Abstract] [Article]
 
Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 1;24(11):1186-200. [Abstract] [Article]
 
2009
Novitch BG, Butler SJ. Reducing the mystery of neuronal differentiation. Cell. 2009 Sep 18;138(6):1062-4. [Abstract] [Article]
 
Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci. 2009 Apr 8;29(14):4484-97. [Abstract] [Article]
 
Karumbayaram S*, Novitch BG*^, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M^, Kornblum HI^, Lowry WE^.  Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr;27(4):806-11. [Abstract] [Article]
 
2008
Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 2008 Jul 31;59(2):226-40. [Abstract] [Article] [Nature News and Views] [Nature Neuroscience News and Views]
 
Briscoe J, Novitch BG. Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):57-70. [Abstract] [Article]
 
2007
Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, Ribeiro A, Mynett A, Novitch BG,  Briscoe J. Interpretation of the sonic hedgehog morphogen gradient by a temporal  adaptation mechanism. Nature. 2007 Nov 29;450(7170):717-20. [Abstract] [Article]
 
2006
Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1551-6. [Abstract] [Article]
 
2005
Marshall CA, Novitch BG, Goldman JE. Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. J Neurosci. 2005 Aug 10;25(32):7289-98. [Abstract] [Article]
 
2003
Novitch BG*, Wichterle H*, Jessell TM, Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 2003 Sep 25;40(1):81-95. [Abstract] [Article] [Preview] [Cover Art]
 
Bylund M, Andersson E, Novitch BG, Muhr J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci. 2003 Nov;6(11):1162-8. [Abstract][Article] [News and Views]
 
Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33. [Abstract] [Article]
 
2001
Novitch BG, Chen AI, Jessell TM. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron. 2001 Sep 13;31(5):773-89. [Abstract] [Article] [Neuron Preview] [Cell Preview] [Cover Art]
 
1999
Novitch BG*, Spicer DB*, Kim PS, Cheung WL, Lassar AB. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr Biol. 1999 May 6;9(9):449-59. [Abstract] [Article]
 
1998
Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG Jr. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 1998 Jan 1;12(1):95-106. [Abstract] [Article]
 
1996
Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol. 1996 Dec;16(12):7043-53. [Abstract] [Article]
 
Novitch BG, Mulligan GJ, Jacks T, Lassar AB. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol. 1996 Oct;135(2):441-56. [Abstract] [Article]
 
1995
Halevy O*, Novitch BG*, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science. 1995 Feb 17;267(5200):1018-21. [Abstract] [Article] [Research News]
 
1994
Lassar AB, Skapek SX, Novitch B. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr Opin Cell Biol. 1994 Dec;6(6):788-94. [Abstract] [Article]
 
* joint first author publications; ^ joint corresponding author papers