March 14, 2017
Zika virus has recently been identified as a global health threat due in large part to its destructive effects on the developing brain, often resulting in microcephaly. Through a collaboration with groups led by our UCLA colleague Genhong Cheng, Zhiheng Xu at the Chinese Academy of Sciences, and Cheng-Feng Qin at the Beijing Institute of Microbiology and Epidemiology, we show that 25-hydroxycholesterol, a molecule produced by cells in response to viral infection, can inhibit Zika virus infection and reduce fetal brain damage.
For more details, please see our paper [here]. Press releases related to the study can be found [here] and [here].